Pharmacogenomic (PGx) or drug-gene testing is used to determine an individual’s response to drugs – both positive and negative. PGx testing in clinical practice aims to personalize an individual’s drug regimen based upon the patient’s genetic makeup. The application combines the knowledge of how drugs work (pharmacology) with the science of the human genome (genomics).
PGx Testing: Precision Pharmacotherapy for PACE
Variant Genes: Health Risks and Liability
In a recent court judgment, two drug companies were ordered to pay the state of Hawaii more than $800 million dollars for failing to warn that a subset of patients faced health risks because they had variant genes and could not fully activate the medication. It is thought that this court decision may establish precedent for litigation around genetics and prescribing. Pharmacogenomic testing (PGx) can be used to determine a patient’s gene status and guide prescribing.
PGx Answers the Most Pertinent Questions
When evaluating a patient’s response to medication therapy, a provider may sometimes wonder:
- Why does this patient need half or twice the standard dose of the drug for it to be effective?
- Why does this drug work for one patient but not another?
- Why does this patient have side effects while others do not, even though the drug and dose are similar?
PGx testing can help answer these questions and more. Using the results of a PGx test, a CareKinesis clinical pharmacist can provide personalized PGx consultation services to a PACE prescriber. The participant’s complete drug regimen is reviewed to determine drug-gene and multi-drug interactions as well as phenotype conversions, which may warrant a prescriber’s attention. Interventions can include monitoring therapy, altering dosage, or changing therapy.
Administering a PGx test can guide a provider to more precise, individualized prescribing. And since the results never change, a PGx test can provide years of benefits for your participants.
“You think, we know what’s going to happen with this drug. But the answer is, no, you don’t.”
George W. Brett, MD, Senior Vice President, Consulting Services, and Chief Medical Officer, Capstone Risk Adjustment Services (former PACE Medical Director)
PGx Testing in PACE Practice
Robert Alesiani, PharmD, BCGP, chief pharmacotherapy officer, Tabula Rasa HealthCare, discusses reasons to test participants and the process of PGx testing.
George W. Brett, MD, senior vice president of consulting and chief medical officer, Capstone Risk Adjustment, and former PACE medical director, describes the results when his program implemented a PGx testing program.
Providers who have collaborated with CareKinesis to use PGx testing in their clinical practices have seen the results manifested through improved medical outcomes for their clients. Learn more about two of these programs, including the reasons they tested participants and the results they saw in the following case studies.
One barrier for implementing PGx testing in PACE is cost. Demonstrating the return on investment (ROI) may be a way to increase adoption into clinical use. A recent study validated the ROI of PGx testing in PACE when used in conjunction with medication reviews and recommendations by CareKinesis clinical pharmacists.
“It’s a different way to practice. It’s reinventing the way you think about prescribing.”
Shirley Huang, MD, Medical Director, TRU PACE, discussing PGx testing.
Watch the recorded webinar to learn more about PGx testing and how precision pharmacotherapy can benefit your PACE participants.
Learn more about PGx testing and how precision pharmacotherapy can benefit your PACE participants. View this special webinar presented by Calvin H. Knowlton, BSciPharm, MDiv, PhD, chairman and CEO, Orsula V. Knowlton, PharmD, MBA, president and chief marketing/new business development officer, and Ankur Patel, MD, MBA, chief medical officer, of Tabula Rasa HealthCare, parent company of CareVention HealthCare/CareKinesis and Pharmastar.
PGx testing is offered by CareKinesis for CareVention HealthCare clients and through a partnership with Pharmastar.